Teratogenesis in repeated pregnancies in antiepileptic drug-treated women
Vajda FJE et al. – Women whose last pregnancy resulted in a fetal malformation have a substantially increased risk of having further malformed fetuses if they become pregnant again while taking the same antiepileptic drugs (AEDs), particularly VPA. This suggests that maternal factors, perhaps genomic, predispose to at least valproate (VPA)–associated malformations. This knowledge, together with information about the outcome of any previous pregnancy, should help in advising women with AED–treated epilepsy who plan further pregnancies.