Culture of human bone marrow-derived mesenchymal stem cells on of poly(l-lactic acid) scaffolds: potential application for the tissue engineering of cartilage
Knee Surgery, Sports Traumatology, Arthroscopy, 08/08/2012
Izal I et al. – Biocompatible poly(l–lactic acid) (PLLA) scaffolds have been developed that can be efficiently loaded with MSCs. The scaffold supports chondrogenic differentiation and extracellular matrix (ECM) deposition that improves the mechanics of the scaffold. Although this improvement does not met the expectations of a hyaline–like cartilage ECM, in part due to the lack of a mechanical stimulation, their potential use in the treatment of cartilage pathologies encourages to improve the mechanical component.