Time profile of viral DNA in aqueous humor of patients treated for VZV acute retinal necrosis using quantitative real-time PCR
Acta Ophthalmologica, 08/21/2012
Chiquet C et al. – qPCR use demonstrated reproducible VZV DNA kinetics with a two–phase evolution: plateau followed by logarithmic decrease. These data suggest that high–dosage antiviral therapy during the conventional 10 days duration is insufficient in most patients. This patient's series responded with a similar decrease in viral load once initiated, this may be used to predict the progression of future patients. The correlation of the viral load threshold with clinical improvement needs to be more clearly defined.