Exploiting the immune response to halt progression of ocular melanoma
Acta Ophthalmologica, 08/08/2012
Mckenna KC et al. – These data suggest a model of ocular tumor regression in splenectomized mice in which CD8+ T cells express IFNγ to induce nitric oxide–independent tumoricidal activity within intratumoral macrophages. Therefore, restoring tumoricidal activity in intratumoral macrophages is critical for CD8+ T cell mediated elimination of ocular tumors



