Transplacental transfer of vancomycin and telavancin
American Journal of Obstetrics and Gynecology, 08/10/2012
Nanovskaya T et al. – The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit.Methods
- The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M–F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes.
- The concentrations of drugs were determined by liquid scintillation spectrometry.
- In the M–F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01).
- The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M–F direction (P < .01), suggesting the involvement of placental efflux transporters.