Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases
Journal of Oncology, 08/03/2012
Eefsen RL et al. – Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic and replacement growth pattern. Although a minor fraction of the patients harboured metastases with different growth patterns, the authors observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient. The result suggests that the growth pattern of liver metastases is not a random phenomenon.