Predictive factors for recurrence progression and cancer specific survival in high-risk bladder cancer
Current Opinion in Urology, 08/03/2012
Faba R et al. – Despite different methodological bias, as short follow–up, a small number of patients and a different definition of prognostic factors, increased evidence supports sex, age, grade, stage, multifocality, history of previous recurrences, carcinoma in situ in the prostatic urethra and early recurrence as prognostic factors for recurrence, progression and cancer specific survival in nonmuscle invasive bladder cancer. Also lymphovascular invasion in transurethral resection (TUR) and new molecular markers are increasingly useful in predicting prognosis and BCG response. Moreover, there is enough evidence to consider the implementation of new specific risk tables for patients treated with Bacillus Calmette–Guerin. In cases with poor prognostic factors after TUR in high–risk bladder cancer early cystectomy should be considered.