Risk factors for visual field progression in the low-pressure glaucoma treatment study
American Journal of Ophthalmology, 07/27/2012
De Moraes CG et al. – While randomization to brimonidine 0.2% was protective compared to timolol 0.5%, lower mean ocular perfusion pressure increased the risk for reaching a progression outcome in the Low–pressure Glaucoma Treatment Study. This suggests that the beneficial effect of randomization to the brimonidine arm was independent of possible differences in ocular perfusion pressures between the 2 treatment arms. The current results and large number of drop–outs in the brimonidine 0.2% arm suggest that more research is necessary before altering clinical practice paradigms.