Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality
Clinical Nutrition, 08/08/2012
Huang T et al. – B vitamin supplementation has a significant protective effect on stroke, but none on the risk of cardiovascular disease (CVD), myocardial infarction (MI), coronary heart disease (CHD), cardiovascular death, or all–cause mortality.Methods
- RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all–cause mortality were searched from PubMed and web of science database.
- Data were independently abstracted by 2 investigators using a standardized protocol.
- The results were pooled with a fixed–effects model using Stata software.
- Data from 19 studies including 47921participants were analyzed using a fixed–effects model.
- The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94–1.03) for CVD, 0.98 (0.92–1.05) for coronary heart disease (CHD), 0.97 (0.90–1.05) for myocardial infarction (MI), 0.88 (0.82–0.95) for stroke, and 0.97 (0.91–1.02) for cardiovascular death, 0.99 (0.95–1.04) for all–cause mortality.
- Blood Hcy levels were decreased in all included RCTs.