Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart Full Text
Cardiovascular Research, 08/03/2012
Hofmann F et al. – The authors suggest that the strongly increased HCN channel activity in hypertrophied myocytes prolongs the repolarization of the ventricular action potential and thereby may increase the arrhythmogenic potential. The results provide for the first time a direct link between an upregulation of ventricular If and a diminished repolarization reserve in cardiac hypertrophy.