mdlinx mdlinx
Latest (498) Full Text Articles (11295) Article Summary

Red blood cell transfusion affects microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis
Intensive Care Medicine,  Clinical Article

Kopterides P et al. – Tissue oxygenation is affected by red blood cell (RBC) transfusion in critically ill septic patients. Monitoring of tissue lactate/pyruvate (LP) ratio by microdialysis may represent a useful method for individual clinical management.

Methods
  • The authors conducted a retrospective study of 37 patients with severe sepsis/septic shock requiring transfusion of one to two RBC units.
  • Interstitial fluid metabolic alterations were monitored by a microdialysis catheter inserted in the subcutaneous adipose tissue.
  • Samples were collected before (T0) and after transfusion at two time–points: T1a and T1b; median post–transfusion times of 120 [interquartile range (IQR); 45–180] and 360 (IQR; 285–320)min.
  • Lactate, pyruvate, glycerol and glucose concentrations were measured with a bedside analyzer, and the lactate/pyruvate (LP) ratio was calculated automatically.

Results
  • RBC transfusions decreased the LP ratio from (T0) 18.80 [interquartile range (IQR); 14.85–27.45] to (T1a) 17.80 (IQR; 14.35–25.20; P<0.05) and (T1b) 17.90 (IQR; 14.45–22.75; P<0.001), while there was also significant interindividual variation.
  • Post–transfusion LP ratio changes at T1a [r=–0.42; 95 % confidence interval (CI),–0.66 to–0.098; P=0.01] and T1b (r=–0.68; 95 % [CI],–0.82 to–0.44; P<0.001) were significantly correlated with the pre–transfusion LP ratio, but not with baseline demographic characteristics, vital signs, severity scores, hemoglobin level and blood lactate.
  • RBC storage time and leukocyte reduction had no influence on the tissue metabolic response to transfusion.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

Last month's top read Top Articles of 2013

1 Association of violence with emergence of persecutory delusions in untreated schizophrenia American Journal of Psychiatry, March 4, 2014    Clinical Article

2 Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes Diabetes Care, March 4, 2014    Clinical Article

3 Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease Clinical Gastroenterology and Hepatology , March 4, 2014    Clinical Article

4 CHIP regulates osteoclast formation through promoting TRAF6 protein degradation Arthritis & Rheumatism, March 5, 2014    Clinical Article

5 Dietary carrot consumption and the risk of prostate cancer European Journal of Nutrition, February 17, 2014    Clinical Article

6 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

7 Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation Journal of Clinical Oncology, March 4, 2014    Clinical Article

8 Risk of dementia after anaesthesia and surgery The British Journal of Psychiatry, March 4, 2014    Clinical Article

9 Vitamin D deficiency and hypocalcemia in an infant with newly diagnosed AML Journal of Pediatric Hematology/Oncology, March 5, 2014

10 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

11 Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

12 Endoscopic characterization of sessile serrated adenomas/polyps with and without dysplasia Endoscopy, March 4, 2014    Clinical Article

13 Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

14 Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality British Journal of Anesthesia, March 27, 2014    Review Article

15 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

16 Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a mendelian randomization study Diabetes, March 4, 2014    Evidence Based Medicine    Clinical Article

17 Scientists reveal new findings for reversing early and late atherosclerosis The Mount Sinai Hospital, March 10, 2014

18 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

19 Molecular subtyping of metastatic renal cell carcinoma: implications for targeted therapy Full Text Molecular Cancer, March 5, 2014    Free full text    Clinical Article

20 Rare coding variants and breast cancer risk: Evaluation of susceptibility loci identified in genome-wide association studies Cancer Epidemiology, Biomarkers & Prevention, March 4, 2014    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Other Topics in Medical Student

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close