Decreased serum carnitine is independently correlated with increased tissue accumulation levels of advanced glycation end products in hemodialysis patients
Nephrology, 07/16/2012
Adachi T et al. – The present study demonstrated that decreased carnitine levels were independently associated with increased skin advanced glycation end product (AGE) levels in hemodialysis (HD) patients. Since carnitine is reported to inhibit the formation of AGEs in vitro, the study suggests that supplementation of carnitine may be a therapeutic target for preventing the accumulation of tissue AGEs and subsequently reducing the risk of cardiovascular disease in HD patients.



