Unicommissural aortic valves: gross, histological, and immunohistochemical analysis of 52 cases (1978-2008)
Cardiovascular Pathology, 07/16/2012
Fealey ME et al. – The functional status of unicommissural aortic valves (UAVs) typically involves stenosis but can vary in type and degree or rarely be normal. In early stenosis (<16 years), the pathology is primarily fibrosis with minimal calcification. UAVs show more calcification compared with age–matched bicuspid or tricuspid aortic valves. The molecular mechanisms of calcification and fibrosis in UAVs remain incompletely understood.