The Structure of an Archaeal Viral Integrase Reveals an Evolutionarily Conserved Catalytic Core yet Supports a Mechanism of DNA Cleavage in trans
Journal of Virology, 07/16/2012
Eilers BJ et al. – The structural superposition on bacterial Holliday junction complexes and similarities in the C–terminal tail with that of eukaryotic Flp suggest that the catalytic tyrosine and an additional active–site lysine are delivered to neighboring subunits in trans. An intramolecular disulfide bond contributes significant thermostability in vitro.