A framework to avoid irrational polypharmacy in psychiatry
Journal of Psychopharmacology, 07/16/2012
Zigman D et al. – The authors present a framework that clinicians can use to avoid the pitfall of irrational polypharmacy. When using combination therapy, clinicians should consider pharmadynamic redundancy, pharmacodynamic interactions, pharmacokinetic interactions and avoid inadequate dosing of medications. Clinicians should also regularly reassess the need for and benefit of continued combination therapy.