BRAF mutation analysis of only one single metastatic lesion can restrict the treatment of melanoma - a case report
British Journal of Dermatology, 07/16/2012
Richtig E et al. – The RAS–RAF–MEK–ERK–mitogen activated protein kinase (MAPK) pathway is a crucial signalling pathway for the growth of malignant cells. BRAF mutations, especially V600E1 and to a lesser extend V600K, are frequently present in melanoma.