Neuromagnetic auditory response and its relation to cortical thickness in ultra-high-risk for psychosis
Schizophrenia Research, 07/05/2012
Shin KS et al. – The primary feature of auditory perception in ultra–high–risk subjects and schizophrenia patients is an encoding deficit that manifests as a reduced M100 dipole moment. The relationship between abnormal M100, thinning of cortical generators and their symptomatology were shown to exist prior to the onset of overt psychosis and progressively worsen over time. Therefore, they may be a potential indicator of the development of schizophrenia.Methods
- The authors investigated the dipole moment of M100 auditory evoked response using a magnetoencephalography in 18 patients with schizophrenia, 16 ultra-high-risk for psychosis and 16 healthy controls, and their relation to cortical thinning on Heschl's gyrus and planum temporale.
- The auditory evoked M100 dipole moment was decreased in the ultra-high-risk subjects and in the patients with schizophrenia.
- Ultra-high-risk subjects showed impaired right M100 dipole magnitude, similar to patients with schizophrenia.
- Robust correlations between the cortical thickness of left Heschl's gyrus and the left M100 dipole moment were found in patients with schizophrenia.
- Moreover, correlations were also evident between right Heschl's gyrus and right M100 in subjects at ultra-high-risk for psychosis.