Connective Tissue Growth Factor-Mediated Upregulation of Neuromedin-U Expression in Trabecular Meshwork Cells and its Role in Homeostasis of Aqueous Humor Outflow
Investigative Ophthalmology & Visual Science, 07/05/2012
Iyer P et al. – The data reveal that connective Tissue Growth Factor (CTGF) influences extracellular matrix (ECM) synthesis, actin cytoskeletal dynamics and contractile properties in trabecular meshwork (TM) cells and that the expression of CTGF is closely regulated by Rho GTPase. Moreover, Neuromedin U, whose expression is induced in response to CTGF, partially mimics the effects of CTGF on actomyosin organization in TM cells, and decreases aqueous humor outflow facility revealing a potentially important role for this neuropeptide in the homeostasis of aqueous humor drainage.