Rapid Angiogenesis Onset after Discontinuation of Sunitinib Treatment of Renal Cell Carcinoma Patients
Clinical Cancer Research, 07/06/2012
Griffioen AW et al. – This study describes, for the first time, the angiostatic response in human primary renal cancers at the tissue level upon treatment with VEGF–targeted therapy. Discontinuation of treatment with tyrosine kinase inhibitors leads to accelerated endothelial cell proliferation. The results of this study contribute important data to the ongoing discussion on the discontinuation of treatment with kinase inhibitors.