Cell Cycle Control in Urothelial Carcinoma: Large-scale Tissue Array Analysis of Tumor Tissue from Maine and Vermont
Cancer Epidemiology, Biomarkers & Prevention, 07/11/2012
Lenz P et al. – The results of this population–based study of histologically confirmed urothelial carcinomas show significant aberration of cell cycle proteins p53, p63, p16, and Ki–67, but not RB or Cyclin D1. P53 showed the most significant heterogeneity with respect to tumor stage and grade, especially when stratified for different staining intensities using novel digital image analysis techniques. The findings do not support that smoking modifies expression of cell cycle proteins.