Serum leptin, resistin and TNF-α levels in patients with systemic sclerosis: the role of adipokines in scleroderma
International Journal of Rheumatic Diseases, 07/06/2012
Pehlivan Y et al. – Leptin, resistin and TNF– α levels were found to be higher in Systemic sclerosis (SSc) in contrast to the control group. These adipokines may have differentiating roles in the pathogenesis of SSc. In order to verify these findings, further clinical studies are needed with larger patient groups.Methods
- Sixteen patients were compared with 30 healthy women of similar age and body mass index.
- Serum leptin, resistin and TNF– α levels were measured by enzyme–linked immunosorbent assay and results were assessed by Mann–Whitney U–test and Spearman's correlation test.
- Leptin levels were significantly increased in the SSc group compared to controls (7789.43 ± 1180.72 pg/mL, 1790.55 ± 333.68 pg/mL, P < 0.0001).
- TNF–α was significantly elevated in patients and it was also positively correlated with leptin (25.30 ± 2.16 pg/mL, 20.95 ± 0.30 pg/mL, P = 0.001), (P = 0.002, r = 0.523).
- There was no association between leptin, resistin, TNF–α levels and skin score, activity score and disease duration in the SSc patients (P > 0.05).