T-type Ca2+ signalling downregulates MEK1/2 phosphorylation and cross-talk with the RAAS transcriptional response in cardiac myocytes
Journal of Molecular and Cellular Cardiology, 07/17/2012
Ruchon Y et al. – This data demonstrate the cross–talk between a GR–mediated aldosterone response, angiotensin II and the ICaT signalling pathways and identify MEK1/2 as a point of connection. This cross–talk results in the fine control of GR– and/or CREB–target gene expression.