Smartest Doc
The efficacy and side effects of levetiracetam on refractory epilepsy in children Full Text
Journal of Pediatric Neurosciences, 07/16/2012
Clinical Article
Incecik F et al. – The results confirm that levetiracetam (LEV), as add–on therapy, was effective in reducing seizure frequency in a variety of seizure types but seems most effective for partial–onset seizures. LEV was also well–tolerated in children.
Methods- The authors evaluated 102 children (56 boys, 46 girls, mean age 96.00 ± 31.15 months) with refractory epilepsy.
- Patients received LEV as add-on therapy.
- Changes in seizure frequency and adverse events were observed.
- Follow-up was conducted at least 6 months after treatment.
- In total, 46 (45.1%) of the 102 children achieved more than 50% seizure frequency reduction, and 16 (15.6%) of these were seizure free.
- LEV reduced seizure frequency by at least 50% in 58.3% of patients with partial seizures, in 32.0% of patients with primary generalized seizures, and in 17.6% of patients with both partial and generalized seizures.
