Parenteral lipid administration to very-low-birth-weight infants—early introduction of lipids and use of new lipid emulsions: a systematic review and meta-analysis
American Journal of Clinical Nutrition, 07/16/2012
Vlaardingerbroek H et al. – The initiation of lipids within the first 2 d of life in VLBW infants appears to be safe and well tolerated; however, beneficial effects on growth could not be shown for this treatment nor for the type of lipid emulsion. Emulsions that are not purely soybean oil–based might be associated with a lower incidence of sepsis. Large–scale randomized controlled trials in preterm infants are warranted to determine whether early initiation of lipids and lipid emulsions that are not purely soybean oil–based results in improved long–term outcomes.Methods
- A systematic review and meta-analysis of publications identified in a search of PubMed, EMBASE, and Cochrane databases was undertaken.
- Randomized controlled studies were eligible if information on growth was available.
- The search yielded 14 studies.
- No differences were observed in growth or morbidity with early lipid initiation.
- The authors found a weak favorable association of non–purely soybean-based emulsions with the incidence of sepsis (RR: 0.75; 95% CI: 0.56, 1.00).