Hypertension resistant to antihypertensive agents com occurs with the progression of diabetic nephropathy in Japanese patients with type 2 diabetes mellitus: a prospective observational study
BMC Nephrology, 06/29/2012
Ito H et al. – Hypertension resistant to antihypertensive agents was common in the patients with type 2 diabetes mellitus and increased with the progression of chronic kidney disease. Although powerful combination therapy using antihypertensive agents is considered necessary for the strict control of blood pressure, this became difficult in individuals who were in advanced stages as graded based on the eGFR and the urinary albumin excretion levels.