Mediating Effects of Aryl-Hydrocarbon Receptor and RhoA in Altering Brain Vascular Integrity: The Therapeutic Potential of Statins
The American Journal of Pathology, 07/05/2012
Chang CC et al. – The results indicate that the binding activities of (beta)–catenin decreased in mouse cerebrovascular endothelial cells treated with 3–methylcholanthrene (3MC). In addition, simvastatin and pravastatin treatment reversed 3MC–mediated alterations in mouse cerebrovascular endothelial cells by RhoA inactivation, and the in vitro findings were substantiated by an in vivo blood–brain barrier assay.