Isoflurane Pretreatment Preserves Adenosine Triphosphate–Sensitive K+ Channel Function in the Human Artery Exposed to Oxidative Stress Caused by High Glucose Levels
Anesthesia & Analgesia, 06/22/2012
Kinoshita H et al. – The authors have demonstrated for the first time a beneficial effect from the pretreatment with isoflurane on the isolated human artery. Pretreatment with isoflurane preserves ATP–sensitive K+ channel activity in the human omental artery exposed to oxidative stress induced by high glucose, whereas the effect seems to be mediated by NADPH oxidase inhibition. Volatile anesthetics may protect human visceral arteries from malfunction caused by oxidative stress.