CETP-mediated cholesteryl ester enrichment of apoB subclasses in type 1 diabetes
European Journal of Clinical Investigation, 06/22/2012
Bagdade JD et al. – While LpB:E + LpB:C:E and LpB:C functioned as cholesteryl ester (CE) acceptors in both groups, these subclasses increased their CE content to a greater degree and accrued more CE per particle in the patients with T1D. As this disturbance in lipoprotein remodelling may increase the cholesterol burden and potential atherogenicity of these apoB subclasses, it may be a previously unrecognized factor that increases cardiovascular risk in patients with T1D.