Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans
American Journal of Physiology - Heart and Circulatory Physiology, 06/26/2012
Barnes JN et al. – These results demonstrate that COX inhibition with Indo unfavorably increases central wave reflection and augments aortic pressure in old but not young subjects. These results suggest that aging individuals have a limited ability to compensate for the acute hemodynamic changes caused by systemic COX inhibition.