Determination of IgG and IgA Antibodies Against Native Gliadin Is Not Helpful for the Diagnosis of Coeliac Disease in Children Up to 2 Years Old
Journal of Pediatric Gastroenterology and Nutrition, 06/14/2012
Richter T et al. – These results do not support the use of assays of anti–nGli to diagnose coeliac disease in young children. IgA–anti–tTG, IgA–EmA, and IgG–anti–dGli perform better than anti–nGli.Methods
- The authors investigated retrospectively 184 children (42 with coeliac disease under normal diet and 142 controls) up to 2 years of age. Immunoglobulin (Ig) A- and IgG-anti-dGli, IgA- and IgG-anti-nGli, IgA- and IgG-anti-tTG, and IgA-EmA were measured in serum.
- Areas under receiver operating characteristics curves, sensitivities, specificities, positive and negative predictive values, positive and negative likelihood ratios, as well as diagnostic odds ratios were calculated.
- From all of the tests investigated, only assays for IgG-anti-dGli, IgA-anti-tTG, and IgA-EmA had high specificity connected with high sensitivity, with high positive predictive values and negative predictive values.
- These assays also showed high positive likelihood ratio at low negative likelihood ratio and high diagnostic odds ratios.