Toxicity Evaluation of Anti-glaucoma Drugs Using Stratified Human Cultivated Corneal Epithelial Sheets
Investigative Ophthalmology & Visual Science, 06/14/2012
Nakagawa S et al. – The carboxyfluorescein permeability assay using human corneal epithelial cell sheets in a serum–free system was the most useful for the quantification of toxicity of ophthalmic solutions. Among the regimens examined, a benzalkonium chloride (BAC) concentration of 0.001% or lower or non–BAC preservative sofZia was suggested to be the least toxic to the ocular surface.