Transcranial magnetic stimulation (tms) for major depression
Depression and Anxiety,  Clinical Article

Carpenter LL et al. – Outcomes demonstrated response and adherence rates similar to research populations. These data indicate that transcranial magnetic stimulation is an effective treatment for those unable to benefit from initial antidepressant medication.

Methods
  • Forty-two US-based clinical TMS practice sites treated 307 outpatients with Major Depressive Disorder (MDD), and persistent symptoms despite antidepressant pharmacotherapy.
  • Treatment was based on the labeled procedures of the approved TMS device.
  • Assessments were performed at baseline, week 2, at the point of maximal acute benefit, and at week 6 when the acute course extended beyond 6 weeks.
  • The primary outcome was change in the Clinician Global Impressions-Severity of Illness from baseline to end of acute phase.
  • Secondary outcomes were change in continuous and categorical outcomes on self-report depression scales (9-Item Patient Health Questionnaire [PHQ-9], and Inventory of Depressive Symptoms-Self Report [IDS-SR]).

Results
  • Patients had a mean ± SD age of 48.6 ± 14.2 years and 66.8% were female.
  • Patients received an average of 2.5 (± 2.4) antidepressant treatments of adequate dose and duration without satisfactory improvement in this episode.
  • There was a significant change in CGI-S from baseline to end of treatment (-1.9 ± 1.4, P < .0001).
  • Clinician-assessed response rate (CGI-S) was 58.0% and remission rate was 37.1%.
  • Patient-reported response rate ranged from 56.4 to 41.5% and remission rate ranged from 28.7 to 26.5%, (PHQ-9 and IDS-SR, respectively).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

1 Midlife dietary vitamin D intake and subsequent performance in different cognitive domains Annals of Nutrition and Metabolism, September 16, 2014    Clinical Article

2 Use of pragmatic community-based interventions to enhance recruitment and adherence in a randomized trial of Tai Chi for women with osteopenia: Insights from a qualitative substudy Menopause, November 10, 2014    Clinical Article

3 Regular fish consumption and age-related brain gray matter loss American Journal of Preventive Medicine, August 15, 2014    Clinical Article

4 Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study International Journal of Cancer, October 3, 2014    Clinical Article

5 Effect of black tea intake on blood cholesterol concentrations in individuals with mild hypercholesterolemia: a diet-controlled randomized trial Journal of the Academy of Nutrition and Dietetics, November 11, 2014    Clinical Article

6 Consumption of garlic and risk of colorectal cancer: An updated meta-analysis of prospective studies Full Text World Journal of Gastroenterology, November 18, 2014    Free full text    Evidence Based Medicine

7 Fiber intake and risk of subsequent prostate cancer in Japanese men American Journal of Clinical Nutrition, November 26, 2014    Clinical Article

8 Associations between the levels of sclerostin, phosphate, and fibroblast growth factor-23 and treatment with vitamin D in hemodialysis patients with low intact PTH level Osteoporosis International, November 10, 2014    Evidence Based Medicine

9 Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women Menopause, November 7, 2014    Clinical Article

10 Dairy products, calcium, and prostate cancer risk: A systematic review and meta-analysis of cohort studies American Journal of Clinical Nutrition, November 26, 2014    Clinical Article

11 Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review Clinical Nutrition, November 21, 2014    Clinical Article

12 Fruit and vegetable intake and rate of heart failure: A population-based prospective cohort of women European Journal of Heart Failure, November 12, 2014    Clinical Article

13 Effect of low salt diet on insulin resistance in salt-sensitive versus salt-resistant hypertension Hypertension, November 26, 2014    Clinical Article

14 Systemic markers of collagen metabolism and vitamin C in smokers and non-smokers with pelvic organ prolapse European Journal of Obstetrics & Gynecology and Reproductive Biology, November 26, 2014    Clinical Article

15 High-fructose diet in adolescence may exacerbate depressive-like behavior Emory's Woodruff Health Sciences Center News, November 21, 2014

16 Association between fatty acid supplementation and prenatal stress in African Americans: A randomized controlled trial Obstetrics and Gynecology, November 26, 2014    Clinical Article

17 Vegetarian diets and glycemic control in diabetes: A systematic review and meta-analysis Full Text Cardiovascular Diagnosis and Therapy, November 20, 2014    Free full text    Evidence Based Medicine    Review Article

18 Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak The Lancet, October 23, 2014    Evidence Based Medicine    Clinical Article

19 Association between sugar-sweetened beverages and type 2 diabetes: a meta-analysis Journal of Diabetes Investigation, November 13, 2014    Evidence Based Medicine    Review Article

20 Tomato juice consumption improves blood antioxidative biomarkers in overweight and obese females Clinical Nutrition, November 13, 2014    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore