C-reactive protein, early life stress, and wellbeing in healthy adults
Acta Psychiatrica Scandinavica, 06/14/2012
Carpenter LL et al. – Lower–quality physical health and wellbeing, but not the presence of mood/anxiety symptoms or early life stress (ELS), were significantly related to plasma C–reactive protein (CRP). Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.Methods
- Ninety-two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders.
- The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self-reported history of early life adversity.
- C-reactive protein showed a significant positive correlation with body mass index (BMI; r = 0.477, P < 0.001).
- Non-specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all P < 0.05 or P < 0.01), after controlling for effect of BMI and other relevant covariates.
- Subthreshold depression symptoms and other indices of mental/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity.