DTI reveals hypothalamic and brainstem white matter lesions in patients with idiopathic narcolepsy
Sleep Medicine, 06/29/2012
Menzler K et al. – The study shows widespread microstructural white matter changes that are not visible on conventional MRI scans in patients with idiopathic narcolepsy. In support of the evidence from patients with symptomatic narcolepsy, the authors found microstructural changes in the hypothalamus, mesencephalon, pons, and medulla oblongata. Changes are in accordance with disturbances of the hypothalamic hypocretin system and its projections to mesencephalic and pontine areas regulating REM sleep.