Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity
European Journal of Immunology, 06/14/2012
Sekar D et al. – The authors propose that CD69 expression on CD39+Treg cells enables them to interact with CD73–expressing CD8+T cells to generate adenosine, thereby suppressing cytotoxicity. These findings aid the understanding of how dying tumor cells limit antitumor immunity.