Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin ii and toll-like receptor 4
Circulation Research, 06/08/2012
Yuen CY et al. – Osteocalcin transforms adventitial fibroblasts to myofibroblasts through stimulating angiotensin II release and subsequent activation of PKCδ/TLR4/reactive oxygen species/cyclooxygenase–2 signaling cascade. This study reveals that the skeletal hormone osteocalcin cross–talks with vascular system and contributes to vascular remodeling.