High DGK-{alpha} and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention
The Journal of Immunology, 06/13/2012
Prinz PU et al. – The results indicate that the tumor–inflicted deficits of TILs are reversible. DGK–α inhibition and provision of IL–2 signals could be strategies to recruit the natural CD8+ T cells to the anti–tumor response and may help prevent inactivation of adoptively transferred T cells thereby improving therapeutic efficacy.



