Homocysteine induces oxidative stress in young adult central retinal vein occlusion
British Journal of Ophthalmology, 06/21/2012
Exclusive author commentary
Devi SRB et al. – Thiobarbituric acid–reacting substance (TBARS) and homocysteine are known to be independent risk factors for central retinal vein occlusion (CRVO). TBARS can be influenced by both homocysteine and total antioxidant capacity, thereby contributing to the aetiopathology of CRVO by increasing oxidative stress.
Dr Narayanasamy Angayarkanni (06/29/2012) comments:
This study reveals that hyperhomocysteiemia and oxidative stress are risk factors for young adult CRVO cases. It was observed that plasma homocysteine (Hcys) can increase the oxidative stress as seen in these cases. This is substatianted by the in vitro study in retinal microvascular endotheial cells exposed to Hcys as reported for the first time.