Zhou L et al. – The meta–analysis indicated the significant association of –11377C/G polymorphism, but not +45T/G or +276G/T polymorphism, with coronary artery disease (CAD) susceptibility. However, large–scale studies with the consideration of gene–gene and gene–environment interactions should be conducted to investigate the associations in future.Methods
- Published literature from PubMed and EMBASE databases were searched.
- Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed– or random–effects model.
- Sixteen studies (4394 cases / 8187 controls) for +45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for +276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for –11377C/G polymorphism were included in the meta–analysis.
- The overall results showed that there was a statistically significant association between –11377C/G polymorphism and CAD (G vs. C: OR=1.15, 95%CI 1.07–1.24).
- Similar results were observed among European (G vs. C: OR=1.11, 95%CI 1.02–1.20) and East Asian populations (G vs. C: OR=1.27, 95%CI 1.11–1.45).
- However, no significant association was found for +45T/G or +276G/T polymorphism with CAD susceptibility.