Smartest Doc
Neurodevelopmental Outcome of Infants Resuscitated with Air or 100% Oxygen: A Systematic Review and Meta-Analysis
Neonatology, 06/11/2012
Evidence Based Medicine
Saugstad OD et al. – Long–term follow–up did not detect any significant differences in these two groups regarding abnormal development. However, the results are imprecise and could be consistent with significant harm or benefit.
Methods- Bibliographic databases were searched.
- In addition, they estimated the effect of loss to follow-up on our analysis of abnormal neurodevelopmental outcome.
- The authors identified 10 studies in which newborn infants had been randomly or quasi-randomly assigned to resuscitation with air or 100% oxygen.
- Three of these 10 studies had available follow-up data.
- A total of 678 infants were enrolled at centers that performed follow-up of these infants.
- Of these, 113 died, leaving 565 infants potentially eligible for follow-up. A total of 414 children were evaluated (73% of eligible children; 195 resuscitated with air and 219 with 100% oxygen).
- In the air group, 12.8% of infants had an abnormal neurodevelopmental outcome, compared with 10.5% in the 100% oxygen group [typical relative risk (RR) 1.24, 95% confidence interval 0.73-2.10].
- This is consistent with an RR of abnormal development as low as 0.41 or as high as 2.28.
