Neuroprotective Effects of Angiotensin II Type 1 Receptor (AT1-R) Blocker via Modulating AT1-R Signaling and Decreased Extracellular Glutamate Levels
Investigative Ophthalmology & Visual Science, 06/04/2012
Fujita T et al. – NADPH oxidase–mediated reactive oxygen species production increased at 12 h after reperfusion. Candesartan may protect neurons by decreasing extracellular glutamate immediately after reperfusion and by attenuating oxidative stress via a modulation of the angiotensin II type 1 receptor signaling that occurs during ischemic insult.