Analysis of 15 patients with systemic lupus erythematosus manifesting with negative immunofluorescence anti-nuclear antibodies after treatment
Song LJ et al. – Antinuclear antibody can be detected in some systemic lupus erythematosus (SLE) patients with negative immunofluorescence anti–nuclear antibodies (IFANA) by changing the detection method and titer. Negative conversion of IFANA often indicates unfavorable prognosis for severe patients.Methods
- Fifteen cases with negative IFANA were identified in 960 patients.
- All of the 15 patients were severe, 11 patients manifested with nephritic range proteinuria and hypoalbuminemia, 8 patients were complicated with severe infection and all of the patients had been treated with glucocorticoid and immunosuppressant.
- Anti–ENA antibodies were positive in 4 of 15 patients.
- Eight patients died after average 1–year follow–up.
- Collectively, negative IFANA is mainly attributed to nephritic–range proteinuria; and large–dose glucocorticoid, immunosuppressant and severe infection are also important factors for negative IFANA.