Interleukin-18 levels reflect the long-term prognosis of acute lung injury and acute respiratory distress syndrome
Journal of Anesthesia,  Clinical Article

Makabe H et al. – The present data demonstrate an inverse correlation between serum interleukin (IL)–18 level and the P/F ratio, suggesting the possible involvement of IL–18 in the pathogenesis of respiratory failure in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Early–stage serum IL–18, IL–12, and tumor necrosis factor (TNF)–α levels appear to reflect the >60–day prognosis in patients with ALI/ARDS.

Methods
  • The study subjects were 38 patients with acute respiratory failure treated at the institution during the 4-year period from April 2004 to March 2008.
  • The underlying clinical condition was defined as acute respiratory distress syndrome (ARDS; n=12) or acute lung injury (ALI; n=26).
  • The serum levels of interleukin (IL)-18, IL-12, and tumor necrosis factor (TNF)-α were measured by enzyme-linked immunosorbent assays.

Results
  • The ARDS group showed significantly higher serum levels of IL-18, IL-12, and TNF-α even at an early stage after disease onset compared with the ALI group.
  • A negative correlation was noted between the PaO2/FIO2 ratio (P/F ratio) and serum IL-18 level.
  • Analysis of all 38 patients with ALI/ARDS revealed a 30-day mortality rate of 7.9 %, 60-day mortality rate of 15.8 %, and 90-day mortality rate of 18.4 %.
  • The early-stage serum levels of IL-18, IL-12, and TNF-α were significantly higher in the non-survivors at 60 and 90days, but not at 30days, than in the corresponding survivors.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

1 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

2 Association of Coffee Consumption With All-Cause and Cardiovascular Disease Mortality Mayo Clinic Proceedings, September 19, 2013    Evidence Based Medicine    Clinical Article

3 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

5 High protein weight loss diets in obese subjects with type 2 diabetes mellitus Nutrition, Metabolism & Cardiovascular Diseases, January 3, 2014    Clinical Article

6 Pathology residency training: time for a new paradigm Human Pathology, March 25, 2014    Clinical Article

7 Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth Obstetrics and Gynecology, July 3, 2014    Clinical Article

8 Anemia in the elderly Current Opinion in Hematology, November 12, 2012

9 Risk of dementia after anaesthesia and surgery The British Journal of Psychiatry, March 4, 2014    Clinical Article

10 Coffee consumption and risk of prostate cancer: A meta-analysis of prospective cohort studies Carcinogenesis, January 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

11 Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease Clinical Nutrition, July 22, 2014    Clinical Article

12 Drug-induced long QT in adult psychiatric inpatients: The 5-year cross-sectional ECG screening outcome in psychiatry study American Journal of Psychiatry, December 11, 2013    Clinical Article

13 Dietary protein and muscle in older persons Current Opinion in Clinical Nutrition & Metabolic Care, December 24, 2013    Review Article

14 Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives The Lancet, June 20, 2014    Review Article    Clinical Article

15 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 15, 2014    Clinical Article

16 Role of herbal medicines in cardiovascular diseases Full Text Middle East Journal of Family Medicine, December 18, 2013    Free full text    Review Article
Exclusive Author Commentary

17 Nuts in the prevention and treatment of metabolic syndrome American Journal of Clinical Nutrition, June 5, 2014    Review Article

18 Virtual reality training helps adults with autism prepare for job interviews Northwestern University Feinberg School of Medicine News, May 15, 2014

19 Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years Full Text Pediatrics, July 12, 2013    Free full text    Clinical Article

20 Possible association between vitamin D deficiency and restless legs syndrome Full Text Neuropsychiatric Disease and Treatment, June 6, 2014    Free full text    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close