Leukocytes from wheezing infants release lower amounts of IL-12 and IFN- compared to non-wheezing infants
Pediatric Pulmonology, 05/30/2012
Falcai A et al. – In this prospective cohort of infants with high risk of developing allergic diseases they observed that RW and non–RW children were exposed to similar levels of endotoxin early in life. LPS–stimulated PBMC from RW infants exposed to higher levels of endotoxin released significantly less IL–12 and IFN–gamma compared to non–RW infants.