Impaired skeletal muscle blood flow control with advancing age in humans: attenuated atp release and local vasodilation during erythrocyte deoxygenation
Circulation Research, 05/30/2012
Kirby BS et al. – Skeletal muscle blood flow during conditions of erythrocyte deoxygenation was markedly reduced in aging humans, and reductions in plasma ATP and erythrocyte–mediated ATP release may be a novel mechanism underlying impaired vasodilation and oxygen delivery during hypoxemia with advancing age. Because aging is associated with elevated risk of ischemic cardiovascular disease and exercise intolerance, interventions that target erythrocyte–mediated ATP release may offer therapeutic potential.