Myofilament ca sensitization increases cytosolic ca binding affinity, alters intracellular ca homeostasis, and causes pause-dependent ca triggered arrhythmia
Circulation Research, 05/30/2012
Schober T et al. – Myofilament Ca sensitization increases cytosolic Ca binding affinity. A major proarrhythmic consequence is a pause–dependent potentiation of Ca release, action potential prolongation, and triggered activity. Increased cytosolic Ca binding represents a novel mechanism of pause–dependent arrhythmia that may be relevant for inherited and acquired cardiomyopathies.