Epistatic rescue of nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and hdac3
Circulation Research, 05/30/2012
Risebro CA et al. – Here authors identify Prox1 as a direct upstream modifier of Nkx2.5 in the maintenance of the adult conduction system and rescue of Nkx2.5 conduction disease phenotypes. This study is the first example of rescue of Nkx2.5 function and establishes a model for ensuring electrophysiological function within the adult heart alongside insight into a novel Prox1–HDAC3–Nkx2.5 signaling pathway for therapeutic targeting in conduction disease.