Depressive symptoms in older people with metabolic syndrome: is there a relationship with inflammation
International Journal of Geriatric Psychiatry, 05/29/2012
Viscogliosi G et al. – Metabolic syndrome and inflammation are independently associated with depressive symptoms in older people. Inflammation may explain cognitive decline too.Methods
- Physical parameters, standard blood analytes, high sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR) were assessed.
- Fifteen-item Geriatric Depression Scale and mini mental state examination (MMSE) were administered.
- One hundred thirty-three subjects were enrolled.
- MetS patients (57) exhibited higher prevalence of depressive symptoms (p < 0.0001), worse cognitive function (p < 0.0001), and higher levels of ESR and hsCRP were higher (p < 0.0001).
- The univariate analysis showed a linear strong correlation of depressive symptoms (p < 0.0001) with the MMSE score (r = -0.422), body mass index (r = 0.414), MetS (r = 0.582), number of MetS components (r = 0.663), fasting blood glucose (r = 0.565), ESR (r = 0.565), hsCRP (r = 0.745), central obesity (r = 0.269; p = 0.002), and high-density lipoprotein cholesterol (r = -0.241; p = 0.005).
- However, the multivariate analysis showed that only age (B = -0.093; p = 0.032), MetS (B = 1.446; p = 0.025), fasting blood glucose (B = 0.039; p = 0.005), and hsCRP (B = 7.649; p < 0.0001) were independently associated with depressive symptoms.