Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
Internal Medicine Journal, 05/30/2012
Evidence Based Medicine
Cheng G et al. – The quantitative meta–analysis showed that diabetes was a risk factor for incident dementia [including Alzheimer's disease (AD), vascular dementia (VD) and any dementia] and mild cognitive impairment (MCI).Methods
- This study examined the association of diabetes with the onset of dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) and mild cognitive impairment (MCI) by using a quantitative meta–analysis of longitudinal studies.
- EMBASE and MEDLINE were searched for articles published up to December 2010.
- All studies that examined the relationship between diabetes and the onset of dementia or MCI were included.
- Pooled relative risks were calculated using fixed and random effects models.
- Nineteen studies met the inclusion criteria for this meta–analysis, and 6184 subjects with diabetes and 38530 subjects without diabetes were included respectively.
- All subjects were without dementia or MCI at baseline.
- The quantitative meta–analysis showed that subjects with diabetes had higher risk for AD (relative risk (RR):1.46, 95% confidence interval (CI): 1.20–1.77), VD (RR: 2.48, 95% CI: 2.08–2.96), any dementia (RR: 1.51, 95% CI: 1.31–1.74) and MCI (RR: 1.21, 95% CI: 1.02–1.45) than those without.
- The quantitative meta–analysis showed that diabetes was a risk factor for incident dementia (including AD, VD and any dementia) and MCI.