Blood transfusions increase circulating plasma free hemoglobin levels and plasma nitric oxide consumption: a prospective observational pilot study
Critical Care, 06/04/2012
Windsant ICV et al. – The data suggest that red blood cells (RBC) transfusion can significantly increase post–transfusion plasma free hemoglobin (fHb) levels and plasma nitric oxide (NO)–consumption in the recipient. This may contribute to the potential pathophysiological mechanism underlying the much discussed adverse relation between blood transfusions and patient outcome. This observation may be of particular importance for patients with substantial transfusion requirements.